Though safely entombed in a crypt deep beneath the unforgiving desert, an ancient queen whose destiny was unjustly taken from her is awakened in our current day, bringing with her malevolence grown over millennia, and terrors that defy human comprehension.

Dashing legionnaire Rick O’Connell stumbles upon the hidden ruins of Hamunaptra while in the midst of a battle to claim the area in 1920s Egypt. It has been over three thousand years since former High Priest Imhotep suffered a fate worse than death as a punishment for a forbidden love—along with a curse that guarantees eternal doom upon the world if he is ever awoken.

One by one the archaeologists who discover the 4,000-year-old tomb of Princess Ananka are brutally murdered. Kharis, high priest in Egypt 40 centuries ago, has been brought to life by the power of the ancient gods and his sole purpose is to destroy those responsible for the desecration of the sacred tomb. But Isobel, wife of one of the explorers, resembles the beautiful princess, forcing the speechless and tormented monster to defy commands and abduct Isobel to an unknown fate.

An ancient Egyptian priest named Imhotep is revived when an archaeological expedition finds his mummy and one of the archaeologists accidentally reads an ancient life-giving spell. Imhotep escapes from the field site and searches for the reincarnation of the soul of his lover.