A big-game hunter for zoos books passage on a Greek shipping freighter with a fresh haul of exotic and deadly animals from the Amazon, including a rare white Jaguar – along with a political assassin being extradited to the U.S in secret. Two days into the journey, the assassin escapes and releases the captive animals, throwing the ship into chaos.
Anja and five friends join anthroplogy student, Dace, on a journey to study a remote, ancient rock painting. Their excitement vanishes when Mel becomes delirious after skinny-dipping in the waterhole. Feverish, bleeding, confused, she physically and mentally regresses to a vicious predatory state. Mel has gone primal. Mel’s lover and friends realise they are the prey as she savagely hunts them down. Before they can escape another one of them starts to regress, posing a hideous choice; kill their friends or be killed by them. Their only hope of survival is through a cave, where Anja learns too late the meaning of the ancient rock art they came to study.
A scattered college kid, Arlo, and his frat-bro roommate, Blake, try to navigate their hyper-masculine tendencies and their aggression boils over when they end up competing for the same girl.
A team of environmentalists investigating “unchartered territory” find that someone, or rather, something has already made the land its home and proceeds to take the team out, one by one. Meanwhile, a young couple hoping for reconciliation with a long lost brother eventually find themselves in the path of the monster.