Something unnatural is happening in the swamps outside Marais, Louisiana. When a mysterious illness strikes the town, CDC investigator (and former Marais native) Abby Arcane is sent to investigate.
When his henchmen fail to capture Swamp Thing, Dr. Arcane uses his Transducer machine to turn them into mutants to attack Swamp Thing. Two kids, Delbert and J.T. along with a game warden, Tomahawk and Bayou Jack with the help of Arcane’s step daughter Abby come to Swamp Thing’s rescue.
11-year-old Jim Kipp and his mother, Tressa are spending some time at her mom’s house in the swamps of Houma. Jim is introduced to the mysteries and the danger of the swamp while Tressa struggles to bond with Jim.